Lymphangiogenesis and Lymphangiogenic Growth Factors
نویسندگان
چکیده
منابع مشابه
Vascular growth factors and lymphangiogenesis.
Blood and lymphatic vessels develop in a parallel, but independent manner, and together form the circulatory system allowing the passage of fluid and delivering molecules within the body. Although the lymphatic vessels were discovered already 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until recently. This is in ...
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VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics. VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated dis...
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ژورنال
عنوان ژورنال: Journal of Reconstructive Microsurgery
سال: 2015
ISSN: 0743-684X,1098-8947
DOI: 10.1055/s-0035-1544179